Learning The Entourage Effect


The Entourage Effect background

The phrase entourage effect was introduced in 1999. While originally identified as a novel method of endocannabinoid regulation by which multiple endogenous chemical species display a cooperative effect in eliciting a cellular response, the term has evolved to describe the polypharmacy effects of combined cannabis phytochemicals or whole plant extracts. The phrase now commonly refers to the compounds present in cannabis supposedly working in concert to create “the sum of all the parts that leads to the magic or power of cannabis”. Other cannabinoids, terpenoids, and flavonoids may be part of an entourage effect. The entourage effect is considered a possible cannabinoid system modulator.


Cannabis Entourage Effect

Hemp mainly contains two compounds: cannabinoids and terpenes. Cannabinoids are present in various forms and compositions. They are mainly comprised of THC, CBD, CBN, CBC, CBG and more. Terpenes are compounds that give a distinct color, odor, and aroma to the plant. Cannabinoids and terpenes interact with chemical receptors located throughout the body in the endocannabinoid system. Each cannabinoid and terpene has a specific biochemical effect on the receptors.

Certain hemp products consist of only one cannabinoid compound; but the collective action of multiple compounds is considered to be a more efficient and prolonged one. The true power is unleashed only when they are used in tandem. When consuming Multi-spectrum products, the cannabinoids act on different receptors in the human body at the same time. This is called “Entourage Effect”.