The Entourage Effect background
The phrase entourage effect was introduced in 1999. While originally identified as a novel method of endocannabinoid regulation by which multiple endogenous chemical species display a cooperative effect in eliciting a cellular response, the term has evolved to describe the polypharmacy effects of combined cannabis phytochemicals or whole plant extracts. The phrase now commonly refers to the compounds present in cannabis supposedly working in concert to create “the sum of all the parts that leads to the magic or power of cannabis”. Other cannabinoids, terpenoids, and flavonoids may be part of an entourage effect. The entourage effect is considered a possible cannabinoid system modulator and is achieved in pain management.
Cannabis Entourage Effect
Hemp mainly contains two compounds: cannabinoids and terpenes. Cannabinoids are present in various forms and compositions. They are mainly comprised of THC, CBD, CBN, CBC, CBG, CBC, and more. Terpenes are compounds that give a distinct color, odor, and aroma to the plant. Cannabinoids and terpenes bind to chemical receptors located throughout the body in the endocannabinoid system. Each cannabinoid and terpene has a specific biochemical effect on the receptors. This works when a particular Endocannabinoid or Phytocannabinoid communicates with a neuron that sends a message to various parts of the body, regulating temperature, pain, nausea, anxiety and more.
Certain hemp products consist of only one cannabinoid compound; but the collective action of multiple compounds is considered to be a more efficient and prolonged one. The true power is unleashed only when they are used in tandem. When consuming Multi-spectrum products, the cannabinoids act on different receptors in the human body at the same time, delivering a vast array of positive results. Some of the compounds are helpful for a particular condition or achieving a certain state of being, while others aid numerous areas of the body. This is called “Entourage Effect”.
Why Different Effects On Individuals
The Entourage Effect also helps explain why different medical strains may have different effects depending on the individual. Since strains can differ vastly in their chemical profiles, they can cause an equally vast number of experiences.
Let’s consider the following example: we all have our own abilities and skills. So when working alone, our output will be determined by our individual limitations. If you meet another person with some different capabilities and skills, and if you bond with that person and work together, then your combined output will be multiplied. Chances of success increase exponentially. Cannabinoids work in a very similar fashion. Each cannabinoid has a set of unique characteristic properties. When using them in tandem the effects will be multiplied. When we combine multiple compounds in their natural state, we don’t end up with the sum of each part; instead, we see a multiplying effect. The different compounds amplify and compliment each other’s chemistry, making the overall plant more effective in addressing unwanted symptoms.
In another example:
The Entourage Effect can be easily understood when considering the individual property of THC. THC is a psychoactive compound, but using the plant as a whole, the effects are different. Other cannabinoids tend to neutralize the effect and deliver a more promising and efficient impact. As it turns out, cannabis contains more active compounds than just THC. Over 85+ cannabinoids have been found to work in conjunction with THC to produce the relief that is often reported by cannabis users.
Scientific studies have proven that cannabis containing more THC composition is likely to produce the psychoactive state of mind. At the same time, an inverse proportion of CBD to THC will produce a more soothing effect to users. This is proof of The Entourage Effect.